Parkinson's disease
Conditions
Interventions
Intervention Group:Unilateral implanted deep brain stimulation
Intervention Group :Bilateral implanted deep brain stimulation
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1) Subjects and their relatives should give written informed consent to the study prior to initiating any procedure related to the study. 2)Age 18-75 years, not limited by sex; 3) diagnosis of primary PD; 4) right-handedness; 5) greater than Five years or more with predominantly tremor and difficulty in drug control (>4 years); 6) excellent response to L-dopa in combination. Currently unable to satisfactorily control symptoms, severe motor complications, or difficulty to tolerate after adequate medical treatment. Medical adverse events; 7) Improvement in motor scores of more than 30% in the MedDRA trial; 8) Left- and right-sided dyskinesias. Differences in MDS-UPDRS III scores greater than 30% (found in a small sample of 8 patients, right and left side symptoms 9) Grades of H-Y grades 2-3, and 10) Patients were well informed of their willingness to treat unilaterally. Full cooperation with study protocols can be coordinated with investigations, follow-up, and associated protocols to fulfill study requirements.
Exclusion criteria
Exclusion criteria: 1) Subjects did not meet the diagnostic criteria for PD; 2) Severe personality disorder, cognitive impairment; 3) Subjects with contraindications to surgery, such as major medical comorbidities or inability to stop anticoagulation; 4) any structural abnormalities on preoperative MRI of the head; 5) contraindications to MRI examination (except for DBS implants or stimulators themselves); 6) pregnancy; 7) subjects who were unable to comply with the tests and follow-up required for completion of the study were enrolled in another study not related to the current study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| UPDRS-III motor score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Local Filed Potential;Structural Analysis of MRI;PD-related drugs. Drug Adjustment; | — |
Countries
China
Contacts
Public ContactWei Wang
West China Hospital of Sichuan University
Outcome results
None listed