Parkinson's Disease
Conditions
Interventions
Probiotics group:BIFICO 2 capsules tid,Bacillus Licheniformis 2 capsule tid
Control group:Keep the original anti Parkinson's drugs
Sponsors
Beijing Friendship Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
40 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1) Be of any age or gender. 2) Meet the diagnostic criteria for Parkinson's disease. 3) Meet the diagnostic criteria of chronic constipation. 1. Symptoms must include 2 or more of the following: (1) at least 25% of bowel movements are strained; (2) at least 25% of bowel movements are dry bulbous or hard; (3) at least 25% of bowel movements are incomplete; (4) at least 25% of bowel movements have anorectal obstruction or blockage; (5) at least 25% of bowel movements require manual assistance (e.g., finger-assisted bowel movements, pelvic floor support); (6) The number of bowel movements is less than 3 times/week. 2. There are few loose stools without the use of laxatives. 3. There is insufficient evidence to diagnose irritable bowel syndrome. Symptoms have been present for at least 6 months prior to diagnosis, and the symptoms in the last 3 months meet the above criteria. 4) Understand the purpose and procedures of the trial and voluntarily participate in the trial, are willing to comply with the contraindications and restrictions specified in the protocol, are able to complete the log and questionnaire as required, and agree to sign a written informed consent form.
Exclusion criteria
Exclusion criteria: 1: Severe cardiovascular disease, neurological or psychiatric disease or other reasons for inability to cooperate with the study, cancer or AIDS. 2: Patients with localized intestinal lesions, intestinal obstruction, toxic megacolon, gastrointestinal tumors and other organic intestinal lesions. 3: Patients with known allergy or hypersensitivity to the test drug or excipients.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Patient assessment of constipation symptom; | — |
Secondary
| Measure | Time frame |
|---|---|
| Unified Parkinson Disease Rating Scale (UPDRS);Constipation Scale;mini-mental state examination;Hamilton Anxiety Scale;Hamilton Depression Scale;Epworth sleepiness score;Hoehn-Yahr;Colon transit time;RBD Questionnaire–Hong Kong; | — |
Countries
China
Contacts
Public ContactHouzhen Tuo
Beijing Friendship Hospital, Capital Medical University
Outcome results
None listed