Study on the mechanism of spermatogenesis affected by varicocele

Study on the mechanism of seminal plasma exosome miR-192a predicting the effect of varicocele surgery - Seminal plasma exosomes predict the outcome of varicocele surgery

Status

Recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2200066450

Enrollment

Unknown

Registered

2022-12-06

Start date

2022-12-12

Completion date

Unknown

Last updated

2023-05-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Male infertility

Interventions

Observation group A:Improvement after surgical treatment

Observation group B:There was no improvement after operation

control group:without treatment

Eligibility

Sex/Gender

Male

Age

20 Years to 45 Years

Inclusion criteria

Inclusion criteria: Male, 24-45 years old, confirmed as varicocele by color Doppler ultrasound, patients with grade II or III varicocele, patients who underwent ligation of spermatic vein under microscope and kept preoperative and postoperative samples, signed the informed consent.

Exclusion criteria

Exclusion criteria: a. Infectious diseases; b. Hereditary diseases; c. Systemic diseases; d. History of trauma and surgical accidents; e. AZF gene deletion; f. Chromosome abnormality; g. Recent and long-term oral drug history.

Design outcomes

Primary

Measure	Time frame
Reproductive hormone;sperm parameters;exosomes;target gene;	—

Countries

China

Contacts

Public ContactHoubin Zheng

NHC Key Laboratory of Male Reproduction and Genetics, Guangdong Provincial Reproductive Science Institute (Guangdong Provincial Fertility Hospital), Human Sperm Bank of Guangdong Province

zhenghoubin@126.com+86 137 1034 7809

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026