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Study on cerebral protective effect of ice cap with mild hypothermia after interventional recanalization of acute cerebral infarction with large vessel occlusion

Study on cerebral protective effect of ice cap with mild hypothermia after interventional recanalization of acute cerebral infarction with large vessel occlusion

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200066362
Enrollment
Unknown
Registered
2022-12-02
Start date
2022-12-10
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Acute cerebral infarction

Interventions

Group A (using ice cap mild hypothermia group):Use ice cap for mild low temperature treatment
Group B (control group):Not use ice cap for mild low temperature treatment

Sponsors

Heyuan People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 100 Years

Inclusion criteria

Inclusion criteria: ? Onset time = 24 hours; ? Age over or equal to 18; ? NIHSS score = 6; ? Patients with acute cerebral infarction in anterior circulation; ? Clinical symptoms and signs or cerebral vascular examination suggest large vessel occlusion; ? The DWI sequence and FLAIR sequence of brain MRI were not matched, indicating that there was brain tissue in ischemic penumbra that could be saved; ? Cerebral angiography confirmed the occlusion of large vessels in the anterior circulation, including the middle cerebral artery, the anterior cerebral artery and the internal carotid artery; ? The patient's family members understand the risk and necessity of surgery and sign the informed consent form for interventional recanalization treatment; ? The patient's family members signed an informed consent form and agreed to participate in the research project.

Exclusion criteria

Exclusion criteria: ? Less than 18 years old; ? There are contraindications of intravascular recanalization; ? Patients with acute cerebral infarction due to posterior circulation large vessel occlusion receiving interventional recanalization treatment, such as vertebral artery, basilar artery, and posterior cerebral artery; ? Unstable vital signs; ? The patient or his family members refused to accept endovascular interventional recanalization therapy; ? The patient or his family refused to participate in the research project.

Design outcomes

Primary

MeasureTime frame
mRS score on the 90th day after operation;

Secondary

MeasureTime frame
Massive cerebral infarction;cerebral hemorrhage;Cerebral hernia;Gastrointestinal bleeding;Arrhythmia;Electrolyte disturbance;

Countries

China

Contacts

Public ContactWensheng Zhang

Heyuan People's Hospital

494172988@qq.com+86 18826401949

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026