Late life depression
Conditions
Interventions
late life depressive patients:none
healthy elder controls:none
Sponsors
Linkou Chang Gung Memorial Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Age 60-80 years old. 2. The Clinical Dementia Rating Scale (CDR) is normal. 3. The Mini-Mental Scale (MMSE) is normal. 4. Literacy or have received education for more than six years. 5. Have normal or corrected vision and hearing. 6. After being assessed by the Test of Nonverbal Intelligence, Third Edition Normal intelligence. 7. Right-handed as assessed by the lateral dominance test.
Exclusion criteria
Exclusion criteria: 1) another Axis I major psychiatric illness, such as bipolar disorder, schizophrenia, and schizoaffective disorder; 2) history of drug or alcohol dependence; 3) illness that impairs cognitive function, such as dementia or head trauma; 4) major comorbid medical illness, such as stroke, uremia, heart failure or metabolic disorders; 5) physical disability which precludes regular follow up; and 6) metal in the body which precludes MRI.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Resting-state fMRI;Anatomical MRI;Diffusion Tensor Imaging;One-back Working Memory Task;Color-word Stroop;Emotional facial expressions task;Negative emotion regulation task; | — |
Secondary
| Measure | Time frame |
|---|---|
| Geriatric Depression Scale;Triggers of Suicidal Ideation Inventory; | — |
Countries
China
Contacts
Public ContactShwu-Hua Lee
Linkou Chang Gung Memorial Hospital
Outcome results
None listed