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Observation on the effect of different local anesthetic formulations under the guidance of pH in nerve group stagnation

Observation on the effect of different local anesthetic formulations under the guidance of pH in nerve group stagnation - Observation on the effect of different local anesthetic formulations under the guidance of pH in nerve group stagnation

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200066295
Enrollment
Unknown
Registered
2022-11-30
Start date
2021-09-30
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Osteoarthritis

Interventions

I group:0.25% ropivacaine
II group:0.25% ropivacaine+ 20mg dexamethasone
III group:0.25% ropivacaine+ 20ug dexmedetomidine
IV group:0.25% ropivacaine+ 20mg dexamethasone+ 20ug dexmedetomidine

Sponsors

The First People’s Hospital of Yunnan Province
Lead Sponsor

Eligibility

Sex/Gender
All
Age
40 Years to 65 Years

Inclusion criteria

Inclusion criteria: (1) Age: 40-65 years. (2) ASA grade I - II. (3) Patients with definite diagnosis and planned unilateral total knee arthroplasty.

Exclusion criteria

Exclusion criteria: (1) Lower limb motor and sensory disorders. (2) Patients allergic to ropivacaine. (3) Severe hepatic and renal insufficiency. (4) Coagulation dysfunction. (5) Lower extremity vascular disease. (6) Diabetes.

Design outcomes

Primary

MeasureTime frame
visual analogue scale;Duration of analgesia;—

Secondary

MeasureTime frame
adverse reactions;—

Countries

China

Contacts

Public Contacthua jin

The First People’s Hospital of Yunnan Province

Jinhuakm@qq.com+86 13888668869

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026