knee osteoarthritis
Conditions
Interventions
Total knee arthroplasty group 1:intraosseous infusion TXA
Total knee arthroplasty group 2:intravenous TXA
Total knee arthroplasty group 3:intraosseous infusion TXA + intravenous TXA
Sponsors
orthopaedic department, Peking Union Medical College Hospital
Eligibility
Sex/Gender
All
Age
20 Years to 80 Years
Inclusion criteria
Inclusion criteria: (1) Patients with primary unilateral total knee arthroplasty; (2) Age >= 20 years old, < 80 years old, gender is not limited; (3) Patients who use aspirin and/or other antiplatelet medication before operation need to stop aspirin for more than 1 week; (4) The subjects gave informed consent and signed the informed consent form.
Exclusion criteria
Exclusion criteria: (1) Allergy to tranexamic acid; (2) Patients with high risk of thrombosis, including previous VTE history, previous myocardial infarction patients, cerebral infarction patients, patients with malignant tumors, and patients with hypercoagulability, are known to be prone to thrombosis. (3) Complicated with other serious organ diseases such as heart, brain, lung, kidney and blood;. (4) Before operation, Hb was less than 11g/L. (5) He received major orthopedic surgery within three weeks before the operation. (6) At present, patients with diseases that have received anticoagulation therapy and patients who have received regular anticoagulation therapy in the past are combined.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| total blood loss; | — |
Secondary
| Measure | Time frame |
|---|---|
| symptomatic venous thrombosis embolism; | — |
Countries
China
Contacts
Public ContactFeng Bin
Peking Union Medical College Hospital
Outcome results
None listed