Osteoarthritis
Conditions
Interventions
Conventional treatment:HA group, 25 mg/week for 5 weeks.
HA+Semaglutide treatment:0.25 mg for the first week, 0.375 mg for the second week, with the maintenance dose of 0.5 mg weekly form 3rd to 24th week.
Sponsors
The First Affiliated Hospital of Jinan University
Eligibility
Sex/Gender
All
Age
50 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age between 50 and 75 years (50 = 28 kg/m²; 3. Diagnosed with Osteoarthritis (OA) based on X-ray and MRI findings, with a Kellgren-Lawrence (K-L) grade between 0 and III; 4. No restrictions based on gender or ethnicity; 5. Voluntary signing of the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Concurrent conditions affecting knee joint function, such as large loose bodies, tumors, tuberculosis, infection, rheumatism, rheumatoid arthritis, or gout in the knee; 2.Significant deformity or pain in the spine, hip, ankle, or foot, or other conditions that affect normal gait; 3.Diagnosed with diabetes, rheumatoid arthritis or autoimmune diseases, parathyroid or kidney diseases, or abnormal liver function; 4.Use of glucocorticoids within the past three months or a history of intra-articular injections; 5.History of infection or previous joint or arthroscopic surgery.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Western Ontario and McMaster Universities Osteoarthritis Index;Body Mass Index, BMI; | — |
Secondary
| Measure | Time frame |
|---|---|
| Weight;inflammatory markers, eg. CRP;Cartilage degeneration; | — |
Countries
China
Contacts
Public ContactZhang Huan-Tian
The First Affiliated Hospital of Jinan University
Outcome results
None listed