Osteoporosis
Conditions
Interventions
Diabetes osteoporosis group:N/A
Sponsors
The Seventh Affiliated Hospital of Sun Yat-sen University
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: Postmenopausal women over the age of 45. Patients with osteoporosis: Those who meet the diagnostic criteria for osteoporosis in the 2017 edition of the Guidelines for Primary Osteoporosis Diagnosis and Treatment meet one of the following three criteria: (1) BMD of the axial bone (lumbar 1-4, femoral neck, or total hip) or the BMD of 1/3 of the distal radius by dual-energy radiography with a T value <=-2.5 (2) previous brittle fractures of the vertebra or hip (3) BMD measurements suggest low bone mass (-2.5 < T value < -1.0) with a history of brittle fractures of the proximal humerus, pelvis, or distal forearm. Patients with diabetic osteoporosis: (1) meet the diagnostic criteria for osteoporosis in the 2017 edition of "Guidelines for Primary Osteoporosis Diagnosis and Treatment", that is, meet one of the following three criteria: (1) BMD of the axial bone (lumbar 1-4, femoral neck, or total hip) or the BMD of 1/3 of the distal radius by dual-energy radiography with a T value <=-2.5 (2) previous brittle fractures of the vertebra or hip (3) BMD measurements suggest low bone mass (-2.5 < T value < -1.0) with a history of brittle fractures of the proximal humerus, pelvis, or distal forearm. (2) It meets the diagnostic criteria of type 2 diabetes in the Chinese Type 2 Diabetes Prevention Guidelines (2020 Edition) formulated by the Chinese Medical Association.
Exclusion criteria
Exclusion criteria: 1. Other diseases affecting bone turnover, such as thyroid diseases, parathyroid diseases, adrenal diseases and other endocrine system diseases; Digestive and renal diseases that affect the absorption of calcium and vitamin D; Rheumatoid arthritis, systemic lupus erythematosus and other immune system diseases; Neuromuscular diseases; Diseases of the blood system; Malignant tumor; 2. Metabolic bone diseases such as rickets and Paget's disease; 3. with severe hepatic and renal insufficiency or cardiovascular and respiratory diseases; 4. Recently used drugs that affect bone turnover, such as glucocorticoids or anti-osteoporosis drugs; 5. any severe lumbar bone disorder or deformation affecting dual-energy X-ray bone mineral density measurement (DXA); 6. Serum calcium levels above 10.4 mg/dL or urinary calcium excretion above 400 mg/gCr; 7. to Aidilol ingredient allergy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Liver and kidney function;Six electrolytes;24 hour urinary biochemistry;Procollagen I N-Terminal Propeptide;Bone specific alkaline phosphatase;ß-C-termial telopeptide of type 1 collagen;parathyroid hormone;25 hydroxyvitamin D;Density of bone;trabecular bone score;long-chain noncoding RNA NEAT1;Fasting blood glucose;Glycosylated hemoglobin;Assessment of islet function; | — |
Countries
China
Contacts
Public ContactLi Fangping
The Seventh Affiliated Hospital of Sun Yat-sen University
Outcome results
None listed