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Study on cortical structure network and gene expression characteristics of ischemic stroke based on neuroimaging transcriptomics coupling

Study on cortical structure network and gene expression characteristics of ischemic stroke based on neuroimaging transcriptomics coupling

Status
Recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200066280
Enrollment
Unknown
Registered
2022-11-30
Start date
2022-12-01
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

ischemic stroke

Interventions

stroke:/
health people:/

Sponsors

The First Affiliated Hospital of Guangxi University of Traditional Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Ischemic stroke patients: 1 accord with the diagnosis of acute ischemic stroke; The onset time was less than 72 hours; 318 <= 80; 42 points <= NIHSS score <= 25 points; 5 No contraindication of MRI; 6 The patient or legal representative gives informed consent and signs the informed consent form. 2. Healthy people: 1 pair of healthy subjects matched by age, gender, education level, right handedness and other factors; 2 No organic brain disease and definite mental disease, 3 no definite history of alcohol and drug abuse; 4 Sign informed consent.

Exclusion criteria

Exclusion criteria: 1. For those who have a history of stroke and left sequelae that affect the outcome evaluation, mRS >= 2 points before the onset of this stroke; 2. Stroke patients confirmed by examination to be caused by brain tumor, brain trauma, blood disease, infectious diseases, genetic disease, rheumatic immune disease, etc; 3. Patients with severe liver and kidney dysfunction (Note: liver dysfunction refers to ALT or AST value greater than 2 times the upper normal limit; renal dysfunction refers to blood creatinine value greater than 2 times the upper normal limit); 4. There are other life threatening serious diseases, and the expected survival time is less than 3 months; 5. Other diseases that significantly limit the evaluation of neurological function or affect the follow-up of patients; 6. Pregnant, planned or lactating women; 7. Those who are currently participating in other intervention clinical trials;

Design outcomes

Secondary

MeasureTime frame
National Institute of Health stroke scale;Modified Rankin Scale;Barthel Index;

Primary

MeasureTime frame
Multimodal image features;

Countries

China

Contacts

Public ContactYufei Wei

The First Affiliated Hospital of Guangxi University of Traditional Medicine

fei1991@163.com15607716517

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026