atopic dermatitis
Conditions
Interventions
Moderate to severe atopic dermatitis group:no intervention
Sponsors
Shenzhen Second People's Hospital
Eligibility
Sex/Gender
All
Age
12 Years to 75 Years
Inclusion criteria
Inclusion criteria: (1)Male or female aged between12-75, >=40Kg, meeting the Hanifin-Rajka criteria for diagnosis of atopic dermatitis, with atopic dermatitis symptoms >=3 years (2)EASI>=16 and weekly mean WP-NRS>=4 (3)The patient didn't reach EASI 90 or whose weekly mean WP-NRS deceased<4 from baseline after 16 weeks of Dupilumab treatment (4)Dermatologists suggest further treatment with upadacitinib based on the patient's signs and symptoms. (5)The informed content is signed by the patient.
Exclusion criteria
Exclusion criteria: (1) The patient is suffering from other skin diseases which will interfere with the assessment of efficacy (2) The patient is allergic to upadacitinib. (3) The patient is suffering from active tuberculosis or active severe infections. (4) The patient is suffering from severe liver function impairment. (5) The patient is suffering from malignant tumor or had a history of malignant tumor within 5 years (except cured cervical carcinoma in situ, skin squamous cell carcinoma or basal cell carcinoma without metastasis). (6) Pregnancy or lactation (7) The patient is excluded in the study due to other diseases, which is evaluated by researchers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The proportion of patients who reach EASI 75 and EASI 90; | — |
Secondary
| Measure | Time frame |
|---|---|
| The proportion of patients who reach EASI 75 and EASI 90;The proportion of patients whose weekly mean WP-NRS deceased=4 from baseline;The proportion of patients whose DLQI deceased >=4 from baseline; | — |
Countries
China
Contacts
Public ContactCuihong Lian
Shenzhen Second People's Hospital
Outcome results
None listed