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To explore the effect and mechanism of repeated transcranial magnetic stimulation combined with cognitive intervention on post-stroke cognitive impairment based on functional near infrared spectroscopy

To explore the effect and mechanism of repeated transcranial magnetic stimulation combined with cognitive intervention on post-stroke cognitive impairment based on functional near infrared spectroscopy

Status
Recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200066236
Enrollment
Unknown
Registered
2022-11-29
Start date
2022-12-01
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

cognitive disorder

Interventions

Cognitive intervention group:Regular training + Cognitive intervention training
rTMS group:Regular training + rTMS stimulation
Combined group:Regular training + Cognitive intervention training + rTMS stimulation

Sponsors

Zhejiang Provincial People's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 70 Years

Inclusion criteria

Inclusion criteria: 1. Meeting the diagnostic criteria for stroke in Diagnostic Essentials of Major Cerebrovascular Diseases in China 2019; 2. The patient was stable and right-handed; 3. Cognitive impairment was confirmed by the simple mental state examination (MMSE). The inclusion criteria of different educational backgrounds were: junior high school education or above <=24 points, 17 points < primary school education <=20 points, illiteracy <=17 points; 4. Volunteer to participate in the study and sign the informed consent.

Exclusion criteria

Exclusion criteria: 1. Patients with metal implants, such as those with cardiac pacemakers; 2. Patients with severe consciousness disorder or unable to cooperate with follow-up treatment evaluation; 3. Have a history of epilepsy, or the onset of epilepsy after the author; 4. Serious functional impairment of the heart, liver, kidney and other organs; 5. Patients with progressive disease and significantly increased intracranial pressure.

Design outcomes

Primary

MeasureTime frame
mini-mental state examination, MMSE;

Secondary

MeasureTime frame
ontreal cognitive assessment, MoCA;Loewenstein occupational therapy cognitive assessment, LOTCA;Barthel index;

Countries

China

Contacts

Public ContactLiu Yong

Zhejiang Provincial People's Hospital

1163535520@qq.com13738100354

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026