perioperative neuro-cognitive disorders
Conditions
Interventions
CIP group:Intraoperative sedation with cyclophenol
Dex group:Intraoperative sedation with dexmedetomidine
Sponsors
Beijing Jishuitan Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1) Patients with hip fracture scheduled for operation. 2) 65–90 years of age. 3)American Society of Anesthesiologists (ASA) physical status scale grade I-III.
Exclusion criteria
Exclusion criteria: 1) patients with a history of psychosis or long-term psychotropic medication use (dementia, schizophrenia), history of chronic analgesic use, or history of alcohol abuse. 2) patients with preoperative delirium 3) patients with hearing and visual impairments as well as those who had any cerebrovascular accidents such as stroke or transient ischemic attack (TIA) within 3 months. 4) History of cardiac insufficiency or echocardiography showed EF<30%; Severe bradycardia (HR<50 beats/minute); II ~III atrioventricular block. 5) patients with communication barriers who could not complete the cognitive function test.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of intraoperative hypotension;Incidence of intraoperative respiratory depression;Incidence rate of arrhythmia during operation; | — |
Countries
China
Contacts
Public ContactGeng Wang
Beijing Jishuitan Hospital
Outcome results
None listed