Anxiety insomnia
Conditions
Interventions
Dexmedetomidine Group:Dexmedetomidine 2.5 ug/kg nasal drip plus oral tablet of insomnia function (vitamin C)
Zolpidem group:The patients were given 1/40 body weight saline nasal drops and 10 mg zolpidem orally
Placebo group:The patients' body weight was 1/40th of the volume of normal saline nasal drip plus oral tablet (vitamin C)
Sponsors
The first affiliated hospital of Gannan Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. ASA classification I-II; 2. Hospital Anxiety and Depression Scale (anxiety component) HADS-A >= 7 points; 3. Insomnia severity index (ISI) >7 points; 4. Patients with oxygen saturation of 95% or more on air inhalation; 5. Patients 18-65 years of age, regardless of gender, who are to undergo elective surgery; 6. Voluntary signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Hospital Anxiety and Depression Scale (depression component) HADS-D >= 7 points 2.NRS pain score >= 7. 3. Presence of alcohol or drug dependence 4. use of psychotropic drugs within 1 week prior to enrollment 5. BMI > 30 kg/m^2 6. Patients with confirmed or suspected sleep apnea syndrome 7. Presence of any intranasal lesion or congenital abnormality in the nose. 8. Abnormal ECG, liver or kidney function. 9. History of allergy to the drugs used in the study. 10. Pregnancy, lactation, and plans to become pregnant in the short term. 11. Those who are unable to understand the content of the relevant scale or have a severe visual impairment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Time to fall asleep;total sleep time;Psychomotor alertness tasks;Leeds sleep rating scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Sleep Quality Digital Rating Scale;mean arterial pressure;heart rate;Blood pressure saturation;adverse reaction; | — |
Countries
China
Contacts
Public ContactLi Chen
The first affiliated hospital of Gannan Medical College
Outcome results
None listed