Post-Stroke Cognitive Impairment
Conditions
Interventions
Control group:Conventional rehabilitation + rTMS sham stimulation
Single-target stimulation group:Conventional rehabilitation + left DLPFC stimulation, affected side M1 sham stimulation
Dual-target stimulation group:Conventional rehabilitation + left DLPFC, affected side M1 stimulation
Sponsors
Shanghai University of Medicine & Health Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for cognitive impairment after stroke, and be diagnosed as the first stroke by head CT or MRI and are in the recovery period (1 to 6 months); 2. Between 18-75 years old, right-handed, male or female; 3. Clear consciousness, stable vital signs, certain oral expression and comprehension ability; 4. The patient had no cognitive dysfunction before the onset of the disease, had mild to moderate cognitive dysfunction after stroke, and had a primary school or above education level, with a score of 9 points = stage II.; 6. No mental illness, no serious aphasia and hearing comprehension impairment; 7. The person or legal guardian agrees and signs the informed consent form and voluntarily cooperates with the test.
Exclusion criteria
Exclusion criteria: 1. Combined with serious lesions of organs and bodies such as heart, lungs, liver, and kidneys; 2. The patient's condition is unstable, the symptoms continue to worsen or new lesions appear again; 3. Accompanied by severe mental or intellectual disabilities or abnormal visual and auditory functions, unable to cooperate with the completion of various functional evaluations; 4. Severe dementia caused by neurodegenerative diseases, severe neurological deficits or congenital or hereditary diseases cannot complete the scale assessment; 5. The scalp has scars, tumors, serious infections, ulcers or trauma, and has undergone surgical treatment on the head or eyes; 6. Patients with a history of epilepsy or a family history of epilepsy; 7. Have a history of mental disorders, alcoholism, and drug abuse; 8. Intracranial metal implants, cochlear implants, pacemakers, cardiac stents, etc.Those with metal electronic devices implanted and the presence of magnetic fields may adversely affect them); 9. Within 3 months before enrollment or during treatment, antidepressant, anxiolytic, sedative and other cortical stimulant drugs have been used, drugs that affect cognitive function have been used or other clinical drug trials have been used; 10. Have a history of rTMS treatment, have a history of dizziness or can not tolerate acupuncture or can not cooperate with treatment for other reasons; 11. Those who are participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fugl-Meyer motor function assessment;Mini-mental State Examination;Modified Barthel Index; | — |
Secondary
| Measure | Time frame |
|---|---|
| Motor evoked potentials;Berg balance scale;Montreal Cognitive Assessment;Digital Span Test;Trail Making Test A and B; | — |
Countries
China
Contacts
Public ContactWang Hong
Shanghai University of Medicine & Health Sciences
Outcome results
None listed