Stenosis after large endoscopic submucosal dissection
Conditions
Interventions
experimental group:Postoperative wound filling with tretinoin + thioglycollate gel
positive control group:Postoperative wound filling with tretinoin + saline
blank control group:Postoperative wounds are filled with saline only
Sponsors
Hainan Hospital, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Endoscopic examination indicated esophageal mucosal lesions, which were brown and had clear boundaries under electron staining. The endoscopic diagnosis criteria of early esophageal squamous cell carcinoma or high-grade intraepithelial neoplasia were met under magnification endoscopy; 2. Endoscopic ultrasound suggested that the lesion was hypoechoic, confined to the mucosa, and the submucosa was continuous and complete; 3. The lesions involved 3/4 or more of the circumferential esophagus; 4. Enhanced esophageal CT showed no invasive tumor growth and no involvement of peripheral lymph nodes; 5. Patients with high-grade intraepithelial neoplasia or intramucosal carcinoma indicated by biopsy pathology, which met the indications of endoscopic ESD treatment.
Exclusion criteria
Exclusion criteria: 1. Definite advanced esophageal cancer patients; 2. Endoscopic ultrasound suggested that the lesions involved submucosa or even deeper, and did not conform to ESD treatment indications; 3. Enhanced esophageal CT indicated peripheral lymph node invasion and distant metastasis; 4. Serious heart and lung disease, serious liver and kidney disease, serious blood system disease; 5. Patients with coagulation dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The duration of drug retention in the wound;Incidence of mild and severe stenosis;The response rate of standard two drug fillers; | — |
Secondary
| Measure | Time frame |
|---|---|
| The number of times the refill drug was appended; | — |
Countries
China
Contacts
Public ContactWeiguang Li
Hainan Hospital, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Outcome results
None listed