gastrointestinal malignant tumor radical surgery
Conditions
Interventions
Group P:inject 40mg of Parecoxib sodium 15 minutes before anesthesia-induced.
Group E:Inject 0.25mg/kg Esketamine before anesthesia induction, 0.25mg/kg/h constant-speed infusion during the anesthesia maintenance period, and stop infusion 30 minutes before the end of the operat
Group PE:Inject Esketamine and Parecoxib sodium according to the methods of groups P and E respectively.
Sponsors
Department of Anesthesiology, Chaohu Hospital Affiliated to Anhui Medical University
Eligibility
Sex/Gender
All
Age
60 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Patients who intend to undergo laparoscopic gastrointestinal malignant tumor radical surgery under general anesthesia; 2. Age >= 60 years old; 3. ASAI - III, Mallampati grade I - II; 4. Receive patient-controlled intravenous analgesia (PCIA) treatment after surgery; 5. There are no serious lesions in important organs such as the heart, lungs and brain, and there are no obvious abnormalities in liver and kidney functions; 6. Sign the informed consent of the study.
Exclusion criteria
Exclusion criteria: 1. Allergic to the drugs needed in this study; 2. Patients with mental illness who are unable to cooperate; preoperative inability to communicate due to cognitive dysfunction or speech impairment; 3. Patients with abnormal heart, liver and kidney function; blood pressure >= 180/100 mmHg; untreated or poorly controlled hypertension; 4. Patients with glaucoma, increased intracranial pressure, hyperthyroidism/alcohodiagnos; 5. Other circumstances in which the researchers judge that the patient is not suitable to participate in the clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of postoperative recovery;Stress response:adrenaline and norepinephrine in plasma; | — |
Secondary
| Measure | Time frame |
|---|---|
| Stress response:adrenaline and norepinephrine in plasma;Total consumption propofol and remifentanil;time of postoperative revival and extubation;the exhaust time and the active time post-operation; | — |
Countries
China
Contacts
Public ContactZhiguo Tao
Department of Anesthesiology, Chaohu Hospital Affiliated to Anhui Medical University
Outcome results
None listed