Cardiac Disease
Conditions
Interventions
Control group:Iron sucorse
Test group:Iron sucorse + rhEPO
Sponsors
Fuwai hospital, CAMS
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Adult patients schedual to recieve on-pump coronary artery graft surgery for first time with age between 18-80 years old. 2. Pre-surgery blood test shows hemoglobin level64.44umol/L(360ug/dl) or transferrin saturation TS<20%.
Exclusion criteria
Exclusion criteria: 1. Non iron deficiency anemia (such as thalassemia); 2. Baseline hemoglobin level lower than 100g/L; 3. Iron overload (ferritin>300ug/L), or hematocrit>45%; 4. Hypercoagulation, thromboembolic tendency, past history including deep vein thrombosis, within acute stage of myocardial infarction, stroke or pulmonary embolism. Intracardiac thrombosis, shedding and peripheral embolism; 5. Severe coronary artery stenosis with refractory angina under adequate drug treatment; 6. Poorly controlled hypertension or diabetes, in the state of hypertension emergency, subacute or diabetes ketosis; 7. Past history of chronic kidney disease or usage of rhEPO or similar drugs; 8. Reoperation or emergency operation; 9. EF<30% before operation, or in the state of cardiac shock requiring endotracheal intubation or mechanically assisted; 10. Any additional cardiac surgery other than left atrial appendage resection; 11. Malignant tumors or other serious systemic diseases; 12. Subjects with irreversible failure of any important organs; 13. Allergy to rhEPO, iron or any experimental drug; 14. Participated in other clinical trials involving drugs or devices within 30 days.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Perioperative period transfusion rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Perioperative period transfusion volumn; | — |
Countries
China
Contacts
Public ContactWang Xianqiang
Fuwai hospital, CAMS
Outcome results
None listed