Chronic kidney disease and preeclampsia
Conditions
Interventions
Patients with chronic kidney disease and pregnancy group:None
Sponsors
Peking University First Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. According to the definition of CKD in KDIGO guidelines, the diagnosis of chronic kidney disease is clear; 2. The diagnosis of intrauterine pregnancy is clear, and the confirmed time of pregnancy is within 11 weeks of pregnancy; 3. 18-45 years old; 4. Recent renal function routine blood test results are available; 5. Be able to follow up the outpatient department of our hospital regularly; 6. Including hypertensive nephropathy and diabetic nephropathy, but without serious diseases of respiratory circulation and other systems; 7. Normal reproductive function; 8. The clinician considers the possibility of continuing the pregnancy; 9. Be willing to sign informed consent; 10. Renal disease was staged from stage I to Stage IIIa.
Exclusion criteria
Exclusion criteria: 1. Multiple pregnancy; 2. Lupus, vasculitis, other systemic immune diseases; 3. Nephropathy caused by abnormal renal structure, urinary obstruction and infectious diseases; 4. The patient or her spouse has hereditary kidney disease (UAKD, Alport, etc.) or other diagnosed hereditary disease; 5. Clinicians evaluate patients with severe kidney disease according to experience (pregnancy with stage ? B and above kidney disease, pregnancy risk is very high), and pregnancy risk is not suitable for pregnancy; 6. Be unwilling or unable to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Placental growth factor;soluble Fms-like tyrosine kinase-1;C3a;C5a;Bb;C4d;membrane attack complex;Uterine artery pulsatility index;Early diastolic notches and S/D values of bilateral uterine arteries; | — |
Countries
China
Contacts
Public ContactYingdong He
Department of Obstetrics and Gynecology, Peking University, First Hospital, Beijing, China
Outcome results
None listed