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Investigating the role of electroacupuncture on brain white matter ultrastructure and cognitive function in patients with post-stroke cognitive impairment based on diffusion tensor imaging

Investigating the role of electroacupuncture on brain white matter ultrastructure and cognitive function in patients with post-stroke cognitive impairment based on diffusion tensor imaging

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200066160
Enrollment
Unknown
Registered
2022-11-25
Start date
2022-12-01
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post-stroke cognitive impairment

Interventions

Cognitive rehabilitation training + electroacupuncture group:Cognitive rehabilitation training: 1 time/day, 20min/time
Electroacupuncture (Baihui, Shenting): 30 min/time, 1 time/d
Cognitive rehabilitation training group:Cognitive rehabilitation training: 1 time/day, 20min/time

Sponsors

Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center)
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: PSCI patients were screened according to the diagnostic criteria for "post-stroke cognitive impairment" in the Expert Consensus on the Management of Post-stroke Cognitive Impairment 2021. 1. Patients with a confirmed stroke on CT or MRI. 2. Presence of cognitive impairment: patient complaint or informed report or experienced clinician's judgment of cognitive impairment following a stroke event, and neuropsychological evidence of impairment in more than one cognitive domain or evidence of previous cognitive decline. 3. The presence of cognitive impairment on the MMSE scale screening with a score of <=17 in the illiterate group, <=20 in the elementary group, and <=23 in the secondary or post-primary group, and exclusion of any other cause other than stroke. 4. after a stroke event and with a duration of illness between 2 weeks and 6 months. 5. age 50-70 years. 6. right sharp hand. 7. No previous treatment or trial related to acupuncture. 8. No concomitant illnesses such as depression or psychiatric symptoms.

Exclusion criteria

Exclusion criteria: 1. Impaired consciousness, severe visual, hearing and aphasic impairment, and those who are unable to complete any other health assessment; 2. cognitive impairment due to Alzheimer's disease, hypothyroidism, traumatic brain injury, other degenerative causes such as Alzheimer's disease (AD), Parkinson's disease, etc.; 3. Those with combined tumors, severe organ and endocrine system diseases. 4. Those who are = 70 years old with a disease duration of = 6 months. 5. Patients with major depressive symptoms [17-item Hamilton Depression Rating Scale (HDRS) score >= 24 (twenty-four)]; 6.Taking medications that may affect cognition: e.g. antipsychotics, sedative-hypnotics, antihistamines, theophyllines, etc.; 7. Contraindications to MRI (metallic foreign bodies in the body, cranial defects, electronic devices, etc.), claustrophobia; 8. People who are participating in other research projects, in addition to those who are considered by the investigators to be unsuitable for clinical trials for other reasons.

Design outcomes

Primary

MeasureTime frame
Montreal Cognitive Assessment (MoCA);

Secondary

MeasureTime frame
Results of DTI data analysis;Cognitive function scores for each module;Stroke Disease Chinese Medicine Evidence Scale Score;

Countries

China

Contacts

Public ContactYisha Guo

Shanghai Yangzhi Rehabilitation Hospital (Shanghai Sunshine Rehabilitation Center)

gyssasha@163.com+86 153 1785 7330

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026