obesity, diabetes
Conditions
Interventions
Sponsors
Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for obesity (BMI >=28kg/m^2); or adult male waist >=90cm, adult female waist >=85cm, or waist-to-hip ratio > 1.0; 2. All the patients meet the diagnostic criteria for type 2 diabetes; 3. Aged 18-65; 4. Glycosylated hemoglobin 6-8%; 5. Did not receive any drug treatment affecting glucose and lipid metabolism or weight loss surgery.
Exclusion criteria
Exclusion criteria: 1. Have been diagnosed with secondary obesity, such as hypothyroidism, Cushing's syndrome, polycystic ovary syndrome, etc.; 2. Severe cardiovascular and cerebrovascular diseases, rheumatic and immune diseases; 3. Severe metabolic diseases, such as diabetic ketoacidosis, hypertonic hyperglycemia, etc.; 4. Patients with type 1 diabetes or other special types of diabetes; 5. Severe liver dysfunction (AST and ALT of liver function exceed the upper limit of normal by more than 2.5 times); 6. Kidney disease or moderate to severe renal insufficiency. eGFR<45 ml/min/1.73m^2); 7. Patients who have taken or are taking loop diuretic, thiazide and other diuretics within the past month; 8. Pregnant and lactating women; 9. Diagnosis of tumor (except stable thyroid papillary carcinoma) or tumor status of chemotherapy, radiotherapy, acute nephropathy, etc.; 10. Patients who have advanced malignant tumors; 11. A history of drug use known to affect glucose and lipid metabolism, such as glucocorticoids, antibiotics, anti-anxiety or antidepressant drugs; 12. Patients who have severe hyperlipidemia and acute attacks of gout; 13. Presence of urogenital system infection; 14. Severe bleeding tendency and inability to complete venous blood collection; 15. There are contraindications of MRI examination, such as patients with cardiac pacemakers, nerve stimulators, artificial metal heart valves, etc.; Patients during pregnancy; Claustrophobic; Epilepsy patients, etc.; 16. Patients who refuse to undergo MRI examination; 17. Patients who are participating in other intervention studies; 18. Other conditions that the researchers consider are not appropriate to study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood glucose;visceral adipose tissue content;insulin;C-peptide;glycosylated hemoglobin;cholesterol;triglycerides;free fatty acids; | — |
Secondary
| Measure | Time frame |
|---|---|
| inflammatory cytokines(IL-2,IL-6,IL- 8,IL-10,TNF-a); | — |
Countries
China
Contacts
Public ContactJing Ma
Department of Endocrinology and Metabolism, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
Outcome results
None listed