Bariatric Surgeries
Conditions
Interventions
Esketamine group:Esketamine infusion: 0.5mg/kg/h
control group:Pump saline pump injection
Sponsors
Affiliated Hospital of Xuzhou Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1. American Society of Anesthesiologists (ASA) physical status II–III; 2. Age between 18 and 65 years; 3. BMI >= 30 kg/m^2; 4. Planned to undergo laparoscopic bariatric surgery prior to registration.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of allergy to any drug used in the study; 2. Previous history of hyperthyroidism and pheochromocytoma, severe cardio-cerebrovascular disease,hypertension grade III (very high risk), severe arrhythmias, or hemodynamic instability; 3. Severe hepatorenal insufficiency ; 4. Recent use of any tricyclic antidepressants, monoamine oxidase inhibitors, sedative, opioid, or sleep-inducing drugs in the past month; 5. Anemia (Hb < 9.0 mg/dl); 6. Unable to cooperate with the researcher for any reason; 7. Hearing or a visual impairment, speech comprehension impairment, mental illness; 8. Refusal to sign informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of postoperative recovery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to extubation;Time to eye opening;Time to spontaneous breathing;postoperation pain;sleep quality;length of hospital stay;time of PACU stay;CNS adverse events(Hallucinations/Vivid dreams/Confusion and disorientation/Visual disturbances);Utilization rate of vasoactive drugs;PONV;postoperative activity time;Postoperative urinary retention;dose of Intra-operative propofol used;dose of Intra-operative remifentanil used;Postoperative analgesic drug dosage;hyoxemia;Qor-40; | — |
Countries
China
Contacts
Public ContactZhiping Wang
Affiliated Hospital of Xuzhou Medical University
Outcome results
None listed