Primary hepatocellular carcinoma
Conditions
Interventions
Sponsors
Peking University Shenzhen Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: (A) Subjects with early hepatocellular carcinoma, age 18-80 years old: patients with stage 0 or stage A liver cancer according to BCLC guidelines, namely, single tumor, or = 3 nodules, single nodule = 3cm, no vascular invasion or extrahepatic metastasis was found in preoperative imaging, liver function was Child Pugh A/B, and PS score was 0. MR multisequence imaging was performed within 1 month before radiofrequency ablation. (B) The subjects underwent ultrasound guided radiofrequency ablation (the ablation range was evaluated to be above the safety boundary of 5mm during the operation), and obtained pathological samples for pathological analysis, immunohistochemical analysis and gene spectrum analysis.
Exclusion criteria
Exclusion criteria: (A) Incomplete MR imaging data; (B) Have received anti-tumor treatment, such as transcatheter hepatic artery chemoembolization (TACE), targeted drug therapy, radiotherapy, etc; (C) Those who cannot perform ultrasound fusion imaging during operation to assess whether the ablation scope covers the lesion and its safe boundary; (C) The obtained pathological specimens failed to meet the relevant analysis of pathological tissues; (D) The maximum diameter of the lesion is less than 1 cm; (D) Infection with hepatitis C virus or other risk factors leading to cirrhosis; (E) There was no anti HBV DNA treatment or the treatment was not standardized.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| early recurrence; | — |
Countries
China
Contacts
Public ContactRonghua Yan
Peking University Shenzhen Hospital
Outcome results
None listed