Population pharmacokinetics of S(+)-ketamine in children
Conditions
Interventions
A:0.5mg/kg of S(+)-ketamine was injected intravenously, and 1ml of arterial blood was collected at 1min, 20min and 4h after drug administration
B:0.5mg/kg of S(+)-ketamine was injected intravenously, and 1ml of arterial blood was collected at 2min, 30min and 6h after drug administration
C:0.5mg/kg of S(+)-ketamine was injected intravenously, and 1ml of arterial blood was collected at 4min, 1h and 8h after drug administration
D:0.5mg/kg of S(+)-ketamine was injected intravenously, and 1ml of arterial blood was collected before, 6min, 1.5h and 12h after drug administration
E:0.5mg/kg of S(+)-ketamine was injected intravenously, and 1ml of arterial blood was collected immediately, 10min, 2h and 24h after drug administration
Sponsors
The Children's Hospital of ZheJiang University of Medicine
Eligibility
Sex/Gender
All
Age
1 Months to 12 Years
Inclusion criteria
Inclusion criteria: (1) American Society of Anesthesiologists (ASA) patient classification I-II. (2) Normal liver and kidney function. (3) No tumor, hematologic, immunologic, or metabolic system disease. (4) Need to be admitted to ICU with a tube.
Exclusion criteria
Exclusion criteria: (1) Bilateral urinary tract obstruction. (2) Hypoproteinemia. (3) Patients on recent liver drug enzyme inhibitors/inducers.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood concentration of S(+)-ketamine;Blood concentration of S(+)-norketamine;Hepatocyte cytochrome P450 enzyme genotype(CYP2B6?CYP3A4?CYP2E1?CYP2A6?CPY2C9);NMDA receptor-related genotypes (GRIN2B, GRIN1, GRIN2A); | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood pressure;Heart rate;Breathing rate;Oxygen saturation; | — |
Countries
China
Contacts
Public ContactYaoqin Hu
The Children’s hospital of ZheJiang University School of Medicine
Outcome results
None listed