Cognitive impairment in elderly patients with heart failure with reduced ejection fraction
Conditions
Interventions
0ne:None
Sponsors
The First Hospital of Shanxi Medical University
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Hospitalized patients with aged 65 years or older 2. New York Heart Function Rating NYHA Grade II-IV 3. Left ventricular ejection fraction < 40% 4. Increased N-terminal precursor natriuretic peptide 5. Montreal Cognitive Assessment Scale < 26 points
Exclusion criteria
Exclusion criteria: 1. Acute decompensated heart failure within one week requires intravenous diuretic, vasodilator or positive inotropic drugs 2. Coronary artery bypass grafting, aortic valve replacement or other major cardiovascular surgery within the last 3 months 3. A variety of serious diseases that affect the clinical course of the subjects, such as acute exacerbation, acute and chronic obstructive pulmonary disease Liver disease, severe renal impairment (eGFR<30mL/min/1.73m2 or regular dialysis subjects), severe anemia, Acute or chronic pancreatitis, present urinary or reproductive infections, any recorded activity or symptoms in the year prior to screening Suspected malignancy or history of malignancy 4. With the exception of heart failure, the researchers identified any disease that caused life expectancy to be less than 1 year 5. Failure to adhere to the study evaluation time for follow-up, or according to the investigator's clinical judgment is not suitable for the trial
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment Scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| mini-mental state examination;left ventricular ejection fraction;N-terminal precursor brain natriuretic peptide;6-min walking distance; | — |
Countries
China
Contacts
Public ContactYao Simin
The First Hospital of Shanxi Medical University
Outcome results
None listed