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Perioperative inflammatory response and short-term prognosis of different anesthesia techniques for patients with hepatocellular carcinoma: Thoracic Paravertebral Block versus Combined Transversus Abdominis Plane Block and Rectus Sheath Block

Perioperative inflammatory response and short-term prognosis of different anesthesia techniques for patients with hepatocellular carcinoma: Thoracic Paravertebral Block versus Combined Transversus Abdominis Plane Block and Rectus Sheath Block

Status
Active, not recruiting
Phases
Early Phase 1
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2200066054
Enrollment
Unknown
Registered
2022-11-23
Start date
2023-01-01
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Hepatocellular carcinoma

Interventions

PVB group:Thoracic Paravertebral Block
TAP group:Combined Transversus Abdominis Plane Block and Rectus Sheath Block

Sponsors

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 65 Years

Inclusion criteria

Inclusion criteria: Patients with ASA status of II-III, aged 18-65 years, BMI between 18 to 28kg/m2 who are scheduled for hepatectomy under general anesthesia.

Exclusion criteria

Exclusion criteria: Patients with previous abdominal surgery, endocrine or immune system diseases(eg. diabetes, thyroid disorder or rheumatic disease), treatment with adrenocortical hormone, non-steroidal anti-inflammatory drugs or other agents affecting immunity before surgery, previous chemotherapy treatment, who are allergic to any drugs used in this trial, NYHA III or ?, history of metastasis through intrahepatic vessels or other organs, infection in puncture sites and etc.

Design outcomes

Primary

MeasureTime frame
Neutrophil-lymphocyte ratio;Concentration of extracellular vesicles and the expression of miRNA within them;VAS score;—

Secondary

MeasureTime frame
classification of complications after surgery;The first postoperative exhaust time;Length of stay;—

Countries

China

Contacts

Public ContactZhang Guohua

National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College

d1974@163.com13520466026

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026