Digestive system diseases
Conditions
Interventions
esketamine group:esketamine 0.15 mg/kg + propofol 1-1.5 mg/kg
saline group:0.9% NaCl 0.15 ml/kg + propofol 1-1.5 mg/kg
Sponsors
The First Affiliated Hostipal of Xi'an Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18 - 65 years; 2. ASA grade I-II; 3. Body mass index (BMI) 18-28 kg/m2; 4. Patient to undergo colonoscopy under sedation/anaesthesia; 5. Voluntary signed informed consent form.
Exclusion criteria
Exclusion criteria: 1. Psychiatric disorders (e.g. schizophrenia, depression, etc.); 2. Bradycardia (heart rate <= 50 beats/min) and severe arrhythmias; 3. Poorly controlled or untreated hypertension, diabetes mellitus, coronary artery disease; 4. Hyperthyroidism or hypothyroidism; 5. History of OSAHS or a combined difficult airway; 6. History of previous psychotropic and narcotic drug abuse; 7. History of abdominal surgery; 8. Pregnant or lactating women; 9. Allergy to experimental drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| consumption of propofol; | — |
Secondary
| Measure | Time frame |
|---|---|
| awakening time;sedation related adverse events;postanesthesia care unit dwell time; | — |
Countries
China
Contacts
Public ContactHan Bin
The First Affiliated Hostipal of Xi'an Medical University
Outcome results
None listed