Restless leg syndrome
Conditions
Interventions
The IPC treatment group:Ischemic preconditioning
Sham IPC control group:Subtherapeutic ischemic preconditioning
Sponsors
Changzhou Second People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. At least 18 years old; 2. Reliable diagnosis of RLS according to the International Classification of Sleep Disorders and the Revised Diagnostic and Coding Manual of the American Academy of Sleep Medicine; 3. Regular dialysis for at least 3 months, 3 times/week, 4 hours each time; 4. The patient's vital signs are basically stable and in good condition, and the expected survival time is more than 2 years; 5. In line with the principles of medical ethics, patients and their families voluntarily sign informed consent; 6. No contraindications related to imaging examination; 7. Subjects taking iron, antidepressants, prescription medications, or hemoperfusion for RLS may be enrolled only if they have been taking a steady dose of medication for more than two months or if they report persistent symptoms after hemoperfusion.
Exclusion criteria
Exclusion criteria: 1. Autar deep vein thrombosis risk assessment Scale score >= 7 points; 2. Patients with severe hypertension (recent blood pressure control systolic blood pressure>160mmHg); 3. Patients with severe swelling of lower limb muscles or joints, limb movement disorder and inability to tolerate limb ischemic preconditioning intervention; 4. Patients with severe infection or acute cardiovascular and cerebrovascular disease within the last 6 months; 5. Uncontrolled infection and unexplained fever and vasculitis, Raynaud's disease, diabetic foot, large capillary brittleness, multiple peripheral neuropathy; 6. coagulopathy or active visceral hemorrhage and malignancy; 7. there are mental or physical limitations (e.g. disorders of consciousness, persons with mental illness) that prevent the collection of data through questionnaires; 8. Have used the IPC device before.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| International RLS research group restless leg severity rating scale; | — |
Secondary
| Measure | Time frame |
|---|---|
| Clinical Global Impressions-Severity of Illness scale;Medical Outcomes Study Sleep Scale;serum creatinine;blood urea nitrogen;albumin;Parathyroid hormone;Serum calcium;Serum phosphorus;resting-state functional MRI; | — |
Countries
China
Contacts
Public ContactTongqiang Liu
Changzhou Second People's Hospital
Outcome results
None listed