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Uncovering the molecular basis of depression in patients based on edge-centric functional connectivity: a transcriptome-neuroimaging correlation study

Uncovering the molecular basis of depression in patients based on edge-centric functional connectivity: a transcriptome-neuroimaging correlation study

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200065982
Enrollment
Unknown
Registered
2022-11-21
Start date
2022-12-01
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

depression

Interventions

Gold Standard:"the Diagnostic and Statistical Manual of Mental Disorders", Fifth Edition (DSM-V)
Index test:Brain region difference, GO/KEGG pathway, cell type analysis, PPI network

Sponsors

Yantai Yuhuangding Hospital
Lead Sponsor

Eligibility

Sex/Gender
All

Inclusion criteria

Inclusion criteria: 1. Met "the Diagnostic and Statistical Manual of Mental Disorders", Fifth Edition (DSM-V); 2. Hamilton Depression Rating Scale (HAMD) with 24 items score > 20; 3. First onset without any treatment; 4. Right-handedness.

Exclusion criteria

Exclusion criteria: 1. Patients and first-degree relatives had psychiatric disorders; 2. Suffering from serious neurological or mental disorders other than MDD; 3. Had any severely unstable disease that required medical treatment; 4. Drug abuse or drug dependence; 5. Had a history of craniocerebral tumor or trauma; 6. Clinically significant laboratory abnormalities; 7. Had MRI examination contraindications.

Design outcomes

Primary

MeasureTime frame
Brain region difference;GO/KEGG pathway;cell type analysis;PPI network;—

Countries

China

Contacts

Public ContactMao Ning

Yantai Yuhuangding Hospital

maoning@pku.edu.cn+86 13105351972

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026