Total knee replacement
Conditions
Interventions
Magnesium sulfate group:Magnesium sulfate was pumped intravenously
Sponsors
Department of Anesthesiology, Lianyungang First People's Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: Inclusion criteria: Patients must meet all the following inclusion criteria to be included in this study: 1. Clearly understand, voluntarily participate in the study, and sign the informed consent; 2. Planned elective knee replacement surgery (operation time <= 2 hours); 3. ASA grade I-III; 4. Clear consciousness, without cognitive dysfunction or other mental diseases; 5. The condition is stable and can cooperate to complete the study.
Exclusion criteria
Exclusion criteria: Exclusion criteria: Patients with any of the following were excluded from the study: 1. BMI 30 kg/m2; 2. Increased serum magnesium level (> 1 mmol/L); 3. Known allergy to one of the study drugs; 4. Severe liver, kidney or heart dysfunction; 5. Preoperative bradycardia with atrioventricular block; 6. Previous treatment with opioids and calcium channel blockers; 7. Acute and critically ill patients (including acute heart failure, acute stroke, acute myocardial infarction, severe infection, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| quality of postoperative recovery (QoR)-15 score 24 hours after operation;Postoperative 24 h numerical rating scale (NRS) score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Total intraoperative anesthetic drug use;QoR-15 score and NRS score at 48 and 72 hours after surgery;Postoperative adverse reactions;First postoperative analgesia time;Intraoperative hemodynamics;Duration of femoral nerve block; | — |
Countries
China
Contacts
Public ContactXiaobao Zhang
Department of Anesthesiology, Lianyungang First People's Hospital
Outcome results
None listed