pancreatic cancer
Conditions
Interventions
Sponsors
Wuwei Tumor Hospital Heavy Ion Center
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-80 years; 2. Pancreatic cancer was diagnosed by pathology or imaging combined with CA199; 3. Patients with UICC TNM eighth version IIA-IIIB; 4. Never received abdominal radiation therapy; 5. No history of other malignant tumors (except cured skin cancer and stage 0 cervical cancer); 6. Renal function, liver function and bone marrow function were basically normal (serum creatinine 9.5 g/dL; White blood cell count >= 3,000/ml; Platelet count >= 100,000/mL; 7. Good physical condition, i.e., ECOG (Eastern Oncology Collaborative Group) 0-2; 8. Expected survival >= 6 months; 9. Prior to radiotherapy, the patient or his/her legal representative had signed the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients who cannot lie still for 30 minutes; 2. Patients with extensive tumor progression and peritoneal involvement; Patients with cancerous ascites; 3. Lose more than 20% of your body weight within six months; 4. Pregnancy (confirmed by serum or urine beta-HCG test) or lactation period; 5. Drug abuse or alcohol dependence; 6. AIDS patients; 7. Associated with uncontrolled systemic, pulmonary, or cardiac disease; 8. With serious comorbidities that prevent the trial protocol from being carried out, including uncontrolled co-morbidities (pulmonary insufficiency, cardiovascular, pulmonary, hepatic, renal, diabetes, etc.), addiction and/or psychiatric disorders; Connective tissue diseases (e.g., scleroderma, systemic lupus) or a history of previous malignancies that might interfere with protocol therapy were excluded; 9. Implantation of a pacemaker or other metal prosthesis is sufficient to affect the delivery of radiotherapy; 10. Patients with poor compliance, including the possibility of not completing the treatment plan or failing to receive prescribed follow-up and examinations; 11. History of other malignancies (other than cured skin cancer and stage 0 cervical cancer); 12. Receive systemic immunotherapy or corticosteroids at the same time; 13. Serum creatinine clearance rate < 30 ml/ min; 14. There are contraindications to radiotherapy; 15. Participated in other drug clinical trials within 30 days prior to enrollment in this trial; 16. Having no or limited capacity for civil conduct; 17. Any medical history that, in the investigator's judgment, may interfere with the trial results or increase the patient's risk; 18. Any circumstances in which the physician considers it inappropriate to participate in the trial; 19. The patient refused to sign the informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Local control rate;Median progression-free survival;Overall survival;Adverse reactions of radiotherapy; | — |
Countries
Chian
Contacts
Public ContactZhang Yanshan
Wuwei Tumor Hospital Heavy Ion Center
Outcome results
None listed