hereditary dermatosis-associated non-melanoma skin cancer
Conditions
Interventions
Surgery group:Surgical excision
Sponsors
Shanghai Skin Disease Hospital
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1. Patients with a clinical diagnosis combined with a molecular diagnosis of hereditary dermatosis with NMSC; 2. Any age, regardless of gender; 3. Lesion size < 2 cm, depth <2 mm, absence of anterior lymph nodes as well as distant metastases; 4. Voluntary participation in the study and signed consent form; 5. Willing to receive ALA-PDT treatment and can tolerate surgery.
Exclusion criteria
Exclusion criteria: 1. Those who have undergone ALA-PDT treatment within 12 weeks and those who apply any other treatment that affects the study; 2. Those with other facial comorbidities that may affect the evaluation of efficacy, such as other light-related skin diseases; 3. Those who have taken phototoxic or photosensitizing drugs within 8 weeks; 4. Clinical and/or pathological evidence of tumor invasion of other organs or tissues; 5. Those who are severely immunocompromised; 6. Keloidal persons; 7. Those with known cutaneous photosensitivity, porphyria, or allergy to ALA, light, or lidocaine; 8. Those with severe medical, psychological, and psychiatric illnesses, infectious diseases, or pregnant or lactating women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Recurrence rate;Number of recurrent lesions; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse reaction;Satisfaction;complete response rate;Lesions clearance rate; | — |
Countries
China
Contacts
Public ContactZhang Guolong
Shanghai Skin Disease Hospital
Outcome results
None listed