postoperative delirium
Conditions
Interventions
Dex-group:continuous infusion of dexmedetomidine
placebo-group:continuous infusion of normal saline
Sponsors
Shanghai General Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Elderly patients with hip fractures scheduled for surgical treatment, including femoral neck fractures, intertrochanteric fractures, and fractures less than 5 cm below the lesser trochanter (generally considered as the upper 1/3 of the femoral shaft); 2. Aged >= 65 years; 3. ASA I-III; 4. Voluntarily sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Compound injury: combined with multiple fractures, such as head, chest, pelvis, limbs and other parts of the hip trauma; 2. Patients with a history of diagnosed Alzheimer's disease; 3. Patients with a history of diagnosed Parkinson disease; 4. The patient has a diagnosed psychiatric history and/or is taking psychiatric drugs; 5. Patients who have developed delirium before surgery or are using drugs (e.g., olanzapine) for delirium); 6. Patients with previous history of alpha 2 receptor agonist allergy or drug resistance; 7. Patients who are using alpha 2-receptor agonists (e.g., clonidine); 8. Patients with a history of acute cerebrovascular disease (stroke or cerebral hemorrhage occurring within 6 months); 9. Patients with 2 degree or 3 degree atrioventricular block or bradycardia and heart rate < 50 BPM on admission; 10. Unable to communicate normally, language barrier; 11. Patients who needed to take sedation or were in a coma after surgery could not complete the follow-up; 12. Have participated in other clinical investigators.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative delirium; | — |
Secondary
| Measure | Time frame |
|---|---|
| degree of postoperative delirium;pain after surgery; | — |
Countries
China
Contacts
Public ContactLi Jinbao
Shanghai General Hospital
Outcome results
None listed