pulmonary nodule
Conditions
Interventions
Experimental group:received esketamine combined with midazolam, propofol, muscle relaxant and dexmedetomidine for anesthesia induction and maintenance
control group:eceived sufentanil, remifentanil combined with midazolam, propofol, muscle relaxant and dexmedetomidine for anesthesia induction and maintenance
Sponsors
Shanghai Changzheng Hospital Anesthesia Department
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: Patients who have a clear preoperative diagnosis and imaging of an occupying lung lesion and are proposed to undergo thoracoscopic lobectomy under general anesthesia and meet the following criteria: 1. Aged 18-65 years, ASA grade I-II, male or female; 2. No preoperative significant organ disease, no cardiopulmonary or hepatic or renal insufficiency, no history of chronic systemic disease, no history of cardiovascular or cerebrovascular disease, no history of psychiatric disease, no history of drug abuse, no history of immune adjuvant therapy, no history of radiotherapy, no history of food and drug allergy; 3. No hormonal and analgesic drugs such as opioids and non-steroidal anti-inflammatory drugs were taken 3 weeks before surgery.
Exclusion criteria
Exclusion criteria: 1. Body mass index > 30 kg/m2; 2. Allergic to the drugs used in this study; 3. Patients with combined cardiopulmonary and hepatic and renal abnormalities, electrolyte disturbances, neuromuscular disorders, severe cardiopulmonary disease, psychiatric disorders, and cognitive impairment; 4. Patients who cannot tolerate one-lung ventilation, patients with a history of rib fracture, ipsilateral lung surgery or history of trauma.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| interleukin-6;interleukin-8;interleukin-10; | — |
Secondary
| Measure | Time frame |
|---|---|
| General Information;Visual Analogue Scale (VAS) scores;postoperative complications; | — |
Countries
China
Contacts
Public ContactYingke Li
Shanghai Changzheng Hospital
Outcome results
None listed