constipation
Conditions
Interventions
Placebo group:Placebo
"Probiotic formula" intervention group:Probiotic formula
Competitive probiotic formula intervention group:Competitive probiotic formula (LifeSpace60 + probiotic capsules for the elderly)
Sponsors
Yixing People's Hospital
Eligibility
Sex/Gender
All
Age
30 Years to 65 Years
Inclusion criteria
Inclusion criteria: Diagnostic and inclusion criteria: 1. Gender or race are not limited, age 30-65 years old, of which the proportion of people aged 45-65 is not less than 60%; 2. Must meet the Rome IV standard; (1) Meet at least 2 or more of the following criteria: 1) Laborious bowel movements or a sense of urgency to defecate (more than 25% of the time); 2) Drainage of bulb or hard manure (more than 25% of the time) (Bristol Fecal Trait Scale 1-2); 3) Feeling of incomplete feces (more than 25% of the time); 4) Feeling of obstruction or blockage in the anorectum (more than 25% of the time); 5) Need manual manipulation to help defecate (such as finger defecation, supporting the pelvic floor) (more than 25% of the time); 6) The number of spontaneous bowel movements is less than 3 times a week; (2) Do not take laxatives and rarely have loose stools; (3) Not enough to diagnose irritable bowel syndrome (IBS) (4) The symptoms appeared >= 6 months before diagnosis, and the above diagnostic criteria were met in the past 3 months 3. Have not used any drugs that affect gastrointestinal motility in the past week; 4. Good compliance, able to comply with the requirements of clinical trials; 5. The subject or guardian has signed the informed consent form; 6. The patient filled in the basic situation questionnaire, dietary structure and living condition questionnaire, and promised to cooperate with the study throughout the trial.
Exclusion criteria
Exclusion criteria: Those who meet the following circumstances will not be selected: 1. Constipation caused by other diseases, functional defecation disorders and drugs, such as: Parkinson's syndrome, anterior rectal bulge pelvic floor spasm, megacolon, hypothyroidism, and long-term use of painkillers; 2. Those who cannot follow the observation due to alcoholism, drug abuse or mental factors; 3. Long-term laxatives; 4. Take probiotic products in the near future (4 weeks) or eat yogurt and probiotic drinks for a long time; 5. Recent (4 weeks) or long-term use of antibiotics; 6. Allergic or intolerant to the ingredients of the test probiotic product; 7. Women who are pregnant or breastfeeding, or who plan to become pregnant or breastfeeding during the study; 8. Subjects deemed unsuitable for enrollment in the opinion of the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Height;Weight;Fecal flora;Fecal flora genomics;Blood routine;Fecal routine;All Blood Cells Analysis;Serum IgE; | — |
Countries
China
Contacts
Public ContactGuohong Qiao
Yixing People's Hospital
Outcome results
None listed