obstructive sleep apnea
Conditions
Interventions
Normoxia:Patients undergoing normoxic exposure continuously inhaled air (O2 21%) through a mask for 50 minutes.
Acute continuous hypoxia, ACH:A 25-minute hypoxia exposure (O2 10~12%) is continuously administered before sleep, followed by inhalation of air (O2 21%) for 25 minutes, with the total exposure time of
Acute intermittent hypoxia, AIH:5×5 min hypoxia exposure (O2 10~12%) are administered. The subjects are alternately exposed to hypoxia for 5 min and 5-min air (O2 21%), for 5 consecutive cycles, with
Sponsors
Renmin Hospital of Wuhan University
Eligibility
Sex/Gender
All
Age
18 Years to 50 Years
Inclusion criteria
Inclusion criteria: 1. Adults aged 18-50 years with a diagnosis of OSA; 2. AHI < 30 events per hour and BMI < 30 kg/m2; 3. Without acute or chronic cardiopulmonary diseases; 4. No prior history of pharyngeal surgery aside from tonsillectomy and no palatine tonsillar hypertrophy (grade III or IV); 5. Signed informed consent before any study procedure.
Exclusion criteria
Exclusion criteria: 1. No predominant OSA evidenced at baseline; 2. Regular use of sedative drugs such as benzodiazepines, opiates, and antipsychotics; 3. Acute nasal congestion during upper airway infection; 4. Known severe respiratory tract allergies, e.g. severe allergic asthma; 5. Any other condition making the subject unsuitable for this study and disallowing participation for the full planned study period, e.g. known history of severe heart failure or severe chronic obstructive pulmonary disease, confirmation of pregnancy; 6. Inability to comply with the planned study procedures or with the study protocol requirements.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Apnea hyponea index, AHI;Oxygen desaturation index, ODI; | — |
Secondary
| Measure | Time frame |
|---|---|
| Adverse events; | — |
Countries
China
Contacts
Public ContactHu Ke
Renmin Hospital of Wuhan University
Outcome results
None listed