Minimal-change nephrotic syndrome
Conditions
Interventions
Glucocorticoid treatment group:Glucocorticoid
Rituximab treatment group:Rituximab
Sponsors
Department of Nephrology, Army Medical Center of PLA
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Voluntary participation and signed informed consent; 2. Unlimited gender, adults (18-75 years old) are firstly diagnosed with nephrotic syndrome; 3. The pathology of renal biopsy was minimal change disease; 4. In complete remission within 8 weeks of adequate glucocorticoid treatment.
Exclusion criteria
Exclusion criteria: 1. Women with recent birth planning, pregnancy or lactation; 2. Unable to understand the potential risks and benefits of the study and to follow-up assessment as required; 3. History of tuberculosis infection; 4. Any existing active infection; 5. HBsAg or HBV-DNA positive, HIV positive, HCV positive; 6. Combined with its diabetic nephropathy or other diseases requiring immunosuppressive agent treatment, such as: other immune diseases, connective tissue diseases, amyloidosis; 7. Clinical diagnosis of secondary minimal change disease (such as lymphoproliferative disease, NSAIDs drug related); 8. Chronic infection is not cured; 9. Infection has occurred in the previous 2 weeks; 10. Kidney replacement (hemodialysis, peritoneal dialysis, or kidney transplantation) treatment; 11. There are any more complex medical problems that may interfere with research behavior or lead to increased risk, such as malignancy, severe coronary heart disease, hematological disease, liver disease; 12. Patients who have participated in clinical trials of other drugs or are participating in other clinical trials within 1 month prior to participating in this trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Urine protein;blood serum albumin; | — |
Secondary
| Measure | Time frame |
|---|---|
| B lymphocyte count;serum creatinine; | — |
Countries
China
Contacts
Public ContactHuanzi Dai
Department of Nephrology, Army Medical Center of PLA
Outcome results
None listed