acute ischemic stroke
Conditions
Interventions
Hypothermia group:After vessel recanalization, 300mL of cold saline at 4? (30mL/min) were administered through the vertebral artery + conventional treatment
Control group:After vessel recanalization, 300mL of 37? saline (30mL/min) were administered through the vertebral artery + conventional treatment
Sponsors
Beijing Luhe Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-80 years; 2. Clinical diagnosis of AIS; 3. Large vessel occlusion in the posterior circulation demonstrated with CTA, MRA or DSA; 4. A baseline National Institutes of Health Stroke Scale (NIHSS) score =8; 5. Less than 8 hours from stroke onset to groin puncture.
Exclusion criteria
Exclusion criteria: 1. Rapid spontaneous improvement in neurological status to an NIHSS 2; 7. Severe arterial blood pressure > 185/110 mmHg; 8. Blood glucose 22.2 mmol/L; 9. Laboratory evidence of coagulopathy (platelet count 50 seconds, or INR > 3.0); 10. Pregnancy; 11. Patients being enrolled or having been enrolled in other clinical trial within 3 months prior to this clinical trial; 12. Informed consent was not obtained.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Symptomatic intracranial hemorrhage; | — |
Secondary
| Measure | Time frame |
|---|---|
| Rate of intracerebral hemorrhage;Rate of fatal intracerebral hemorrhage;Rate of death;National Institutes of Health Stroke Scale score at 24 hours;National Institutes of Health Stroke Scale score at 7 day;Final infarct volume;Modified Rankin scale at 90 days;Rate of functional independence (mRS 0-2) at 90 days;mRS 0-3 at 90 days;vasospasm;pneumonia;urinary infection; | — |
Countries
China
Contacts
Public ContactZhe Cheng
Beijing Luhe Hospital, Capital Medical University
Outcome results
None listed