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Effect and mechanism of SGLT2 inhibitor on cardiac structure and function in patients with type 2 diabetes mellitus

Effect and mechanism of SGLT2 inhibitor on cardiac structure and function in patients with type 2 diabetes mellitus

Status
Active, not recruiting
Phases
Phase 4
Study type
Observational
Source
ChiCTR
Registry ID
ChiCTR2200065792
Enrollment
Unknown
Registered
2022-11-15
Start date
2022-06-22
Completion date
Unknown
Last updated
2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

dibetes

Interventions

SGLT2 inhibitors group:None
Non-SGLT2 inhibitors group:None

Sponsors

Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine
Lead Sponsor

Eligibility

Sex/Gender
All
Age
18 Years to 80 Years

Inclusion criteria

Inclusion criteria: 1. Chinese, no gender limit, aged 18-80 years; 2. Meet the clinical diagnosis of type 2 diabetes mellitus; 3. Meet the clinical diagnosis of acute myocardial infarction; 4. In addition to lifestyle intervention, diabetes mellitus requires at least one hypoglycemic drug treatment (including sulfonylureas, metformin, acarbose, Voglibose, thiazolidinediones, glienides, DPP4 inhibitors, GLP-1 receptor agonists, insulin, etc.); Since most patients with acute myocardial infarction are complicated with heart failure, drugs contraindicated or carefully used for acute myocardial infarction and heart failure should be avoided during treatment, such as thiazolidinediones (pioglitazone, rosiglitazone), DPP4 inhibitors (saxagliptin, alogliptin), metformin, etc.; 5. The patient has clear consciousness and can satisfy normal communication; 6. Good compliance, able to understand and implement the doctor's advice.

Exclusion criteria

Exclusion criteria: Glomerular filtration rate (eGFR) < 45mL/min/1.73m^2.

Design outcomes

Primary

MeasureTime frame
left ventricular end-systolic volume index;

Secondary

MeasureTime frame
left ventricular mass;markers of myocardial infarction;cardiovascular event;

Countries

China

Contacts

Public ContactShen Long

Renji Hospital Affiliated to Shanghai Jiao Tong University School of Medicine

shenlong@renji.com+86 13391157250

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 8, 2026