Intestinal microecological imbalance related diseases
Conditions
Interventions
FMT treatment group:fecal microbiota transplantation
Sponsors
West China Hospital, Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1. Donor selection criteria: (1) Voluntarily participate in the test and sign the informed consent; (2) Aged 18-55 years, no gender limit; (3) No medication (such as antibiotics, antiviral, antifungal drugs, hormones, immunosuppressants, chemotherapy drugs, diet drugs, etc.) for nearly 6 months. Except birth control pills); (4) No high-risk sexual behavior (such as sexual contact with HIV patients, drug users, syphilis, etc.) in the past 6 months; (5) No tattoo or piercing; (6) No history of infectious diseases (such as hepatitis, syphilis, HIV, tuberculosis, malaria, schistosomiasis, etc.) or history of travel to epidemic areas; (7) No acute or chronic intestinal diseases (such as acute or chronic enteritis, functional bowel disease, inflammatory bowel disease, intestinal polyps or malignant tumors, etc.); (8) No blood transfusion; No history of drug use; Regular bowel movements are regular, formed and smooth. 2. Acceptance criteria: (1) Voluntarily participate in the test and sign the informed consent; (2) Intestinal diseases associated with intestinal microecological imbalance that have been clearly diagnosed include pseudomememonitis CDI, antibiotic-associated diarrhea, irritable bowel syndrome, ulcerative colitis, Crohn's disease, intractable constipation, and radiation enteritis; (3) Parenteral diseases associated with intestinal microecological imbalance that have been clearly diagnosed include non-alcoholic fatty liver disease, childhood autism, Parkinson's disease, metabolic diseases, and intestinal complications of organ transplantation.
Exclusion criteria
Exclusion criteria: 1. Donor exclusion criteria: (1) BMI>=28 kg/m^2 or BMI<=18 kg/m^2; (2) Atopic diseases (such as allergic rhinitis, allergic asthma, atopic dermatitis, etc.); (3) Depression, anxiety and other mental diseases; Diseases requiring maintenance treatment with drugs; (4) Chronic diseases (such as cirrhosis, diabetes, hypertension, coronary heart disease, asthma, chronic obstructive pulmonary disease, etc.); (5) Diseases of the nervous system or nervous system degeneration; (6) Autoimmune diseases (e.g., celiac disease, arthritis, multiple sclerosis, connective tissue disease, psoriasis); (7) History of gastrointestinal surgery (except appendectomy); (8) Family history of the following diseases (siblings and parents) : Crohn's disease, ulcerative colitis, celiac disease, colorectal cancer, polyposis, diabetes, psycho-psychological disorders, and other genetic disorders; (9) Gastrointestinal discomfort in the last 1 month: such as any moderate to severe upper gastrointestinal discomfort, diarrhea, constipation, moderate to severe abdominal distension, moderate to severe nausea, painful defecation, fecal mucus, blood in the stool or any blood signs related to defecation; (10) Have a history of diarrhea and intestinal lavage in the past 3 months. 2. Exclusion criteria for receptors: (1) Contraindications for gastroenteroscopy and mucosal biopsy, such as severe malnutrition or severe immune deficiency, coagulopathy, oral anticoagulants, severe damage of intestinal mucosa, complicated with severe infection, acute myocardial infarction, respiratory failure, etc.; (2) Can not cooperate with clinical follow-up; (3) Pregnant or lactating patients in the medical history.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Relief of clinical symptoms; | — |
Secondary
| Measure | Time frame |
|---|---|
| Alterations in the intestinal microbiota; | — |
Countries
China
Contacts
Public ContactLiu Ling
West China Hospital, Sichuan University
Outcome results
None listed