IgA nephropathy (lgAN)
Conditions
Interventions
Treatment group:Conventional treatment + Yishenhuashi Granule
Control group:Conventional treatment
Sponsors
Longhua Hospital, Shanghai University of Traditional Chinese Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Healthy volunteers: (1) Healthy adults, aged between 18 and 75 years, no gender or ethnicity limit; (2) Informed consent, and sign the informed consent. 2. Patients with IgAN: (1) Aged 18-75 years, no gender or ethnicity limit; (2) Primary IgAN was confirmed by renal biopsy and clinical examination; (3) TCM syndrome differentiation of spleen deficiency and dampness; (4) CKD1-2 stage before treatment: eGFR (EPI formula) >=60ml/min; (5) Before treatment, 24 hours urinary protein quantity <=3.0g; (6) Informed consent, and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients who have received glucocorticoids, immunosuppressants, cytotoxic drugs and other treatments within the last 6 months; 2. Patients with acute or acute nephritis; 3. Complicated with life-threatening complications such as severe infection; 4. Patients with active hepatitis B and transaminase abnormalities in continuous liver function test; 5. Patients with malignant tumors or a history of malignant tumors, HIV infection, mental illness, acute central nervous system diseases, severe gastrointestinal diseases, and hormone use prohibited; 6. Patients with abnormal glucose metabolism and significantly elevated blood glucose (including impaired fasting blood glucose and abnormal glucose tolerance); 7. Pregnant or lactating patients; 8. Being enrolled in other clinical trials; 9. Patients with serious diseases and dysfunction of other organs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 24-hour urinary protein quantitation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Estimate glomerular filtration rate (eGFR);Urine red blood cell count;TCM syndrome curative effect; | — |
Countries
China
Contacts
Public ContactZhong Yifei
Longhua Hospital, Shanghai University of Traditional Chinese Medicine
Outcome results
None listed