Sleep Disordered Breathing (SDB)
Conditions
Interventions
intervention group:Continuous Positive Airway Pressure
control group:Conventional Therapy
Sponsors
Shanghai Sixth People's Hospital
Eligibility
Sex/Gender
Female
Age
20 Years to 45 Years
Inclusion criteria
Inclusion criteria: Pregnant women who agree to participate in the trial and sign an informed consent form meet all of the following conditions: 1. Aged 20-45 years; 2. Pregnant women between 26 and 34 weeks of gestation; 3. Suffer from SDB disease (AHI>=5 times/hour); 4. A diagnosis of preeclampsia (24-hour systolic blood pressure >140/90 mmHg and albuminuria >300mg) by an obstetrician-gynecologist; 5. Can tolerate CPAP therapy; 6. Consent to hospitalization in anticipation of treatment; 7. Meet expected treatment conditions; 8. Able to complete relevant tests and follow up.
Exclusion criteria
Exclusion criteria: 1. History of eclampsia in previous pregnancies; 2. Termination of pregnancy upon request without indications for termination of pregnancy; 3. DIC (INR > 2); 4. Platelet =125µmol/L, liver transaminase >=500IU/L); Pulmonary edema; Left heart failure); 6. Previous SDB treatment, such as CPAP, surgery, and oral orthotics; 7. Smoking, alcohol or drug addiction; Or is using psychotropic drugs, sedatives, narcotics, etc.; 8. The investigator did not consider it suitable to participate in this clinical trial.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blood pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| soluble fms-like tyrosine kinase-1;placental growth factor;24-hour urinary protein;hepatic and renal function;platelet count; | — |
Countries
China
Contacts
Public ContactLi Xinyi
Shanghai Sixth People's Hospital
Outcome results
None listed