Disturbance of sleep rhythm
Conditions
Interventions
intervention group:Probiotic Supplements
control group:Placebo
non rotating nurse observation group:N/A
Sponsors
The First Hospital of Hebei Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 35 Years
Inclusion criteria
Inclusion criteria: 1. Inclusion criteria of study group: (1) Have worked shifts for at least 12 weeks, one night shift every 4 days; (2) Type of Mediterranean diet; (3) No gender limit, aged 18-35 years; (4) Sign the informed consent; (5) No cognitive impairment as assessed by Montreal Cognitive Scale. 2. Inclusion criteria of control group: (1) Nurses who have not been on shift for at least 12 weeks; (2) Type of Mediterranean diet; (3) No gender limit, aged 18-35 years; (4) Sign the informed consent; (5) No cognitive impairment as assessed by Montreal Cognitive Scale.
Exclusion criteria
Exclusion criteria: 1. Suffer from mental disorders or epilepsy; 2. Patients with mental health problems who are receiving treatment or within six months prior to enrollment; 3. Patients with severe physical diseases or organic brain lesions; 4. Patients with gastrointestinal diseases such as Crohn's disease and ulcerative colitis; 5. Taking antibiotics or probiotic supplements in the current or 3 weeks prior to enrollment; 6. Patients planning pregnancy, pregnancy or lactation; 7. Undernourished or obese (BMI =30); 8. Patients with substance dependence such as drugs and alcohol; 9. Accompanied by severe sleep disorders, such as sleep apnea and restless legs; 10. Participating in other studies, which may affect the results of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Gut microbiota abundance; | — |
Countries
China
Contacts
Public ContactWang Yumei
The First Hospital of Hebei Medical University
Outcome results
None listed