infertility
Conditions
Interventions
Case series:N/A
Sponsors
Affiliated Hospital of Shandong University of Traditional Chinese Medicine
Eligibility
Sex/Gender
Female
Age
35 Years to 42 Years
Inclusion criteria
Inclusion criteria: 1. Aged 35-42 year, women undergoing IVF-ET and using antagonist regimen; 2. Expected NOR (normal responder) : 7 <= basal sinus follicle number (AFC) <= 15; 1.2 ng/ml <= anti-muller in vitro hormone (AMH) <= 4 ng/ml; Basal follicle stimulating hormone (FSH) level < 10 mIU/ml; 3. No previous history of IVF cycle cancellation with low or high ovarian response; Expected DOR (normal responder): basal sinus follicle number (AFC) <=5; Anti-muller test-tube hormone (AMH) <= 1.2ng /ml.
Exclusion criteria
Exclusion criteria: 1. BMI>=28kg/m^2; 2. IVF/ICSI attempts >= 3 times; 3. Patients with a history of recurrent abortion and repeated implantation failure; 4. Abnormal reproductive system development, male and female chromosome karyotype has one abnormal; 5. Endocrine disorders (diabetes mellitus, hyperprolactinemia, thyroid insufficiency, congenital adrenal hyperplasia, Cushing's syndrome or polycystic ovary syndrome); 6. Untreated moderate to severe endometriosis, submucosal fibroids, multiple endometrial polyps, pelvic inflammatory disease, uterine malformations, Asherman syndrome, and hydrosalpinx; 7. Currently participating in another interventional clinical trial or other in vitro fertilization contraindications.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Number of MII oocyte;Transcriptomic landscape; | — |
Secondary
| Measure | Time frame |
|---|---|
| High quality embryo rate;Two-pronuclear fertilization rate;Number of oocytes;Incidence of ovarian hyperstimulation syndrome;Available quality embryo number; | — |
Countries
China
Contacts
Public ContactGuo Ying
The First Clinical Medical College of Shandong University of Chinese Medicine/Affiliated Hospital of Shandong University of Chinese Medicine
Outcome results
None listed