None listed
Conditions
Interventions
Group A:Esketamine+ erector spinae plane block
Group B:Placebo+ erector spinae plane block
Group C:Simple general anesthesia
Sponsors
Ya'an People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing elective unilateral thoracoscopic lobectomy; 2. Aged range from 18 to 65 years, no gender limit; 3. Body mass index (BMI) 18.5 ~ 24kg/m^2; 4. ASA grading ? ~ ?.
Exclusion criteria
Exclusion criteria: 1. Patients with a history of alcohol and drug abuse, chronic pain and neuropathy; 2. Patients with diabetes who are allergic to esketamine and ropivacaine, have coagulation dysfunction, infected at the injection site, or have poor blood sugar control; 3. Patients with liver and kidney dysfunction; 4. Patients with mental illness who cannot cooperate and communicate with others; 5. Any of the following contraindications exist in the use of Esketamine injection: (patients with serious risk of elevated blood pressure or intracranial pressure; Patients with intraocular hypertension, glaucoma or penetrating ocular trauma; Patients with poorly controlled or untreated hypertension and resting systolic/diastolic blood pressure exceeding 180/110mmHg; Patients with untreated or undertreated hyperthyroidism); 6. The patient refuses to participate.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Numeric Rating Scale (NRS) score for pain; | — |
Secondary
| Measure | Time frame |
|---|---|
| Numeric Rating Scale (NRS) score for pain;Numeric Rating Scale (NRS) score of incision pain;Remifentanil dosage;PCIA pressing times, dosage;Chronic pain occurrence;Times of remedial analgesia;Rating of chronic pain impact on life;Level of chronic pain management measures;Patient satisfaction with postoperative pain management;Level of natural killer cells (%);Level of CD4+T cells (%);Level of CD8+T cells (%);Hypotension;Hypertension;Tachycardia;Bradycardia;Use of vasopressors;Use of atropine;Nausea and vomiting;Adverse events (Respiratory depression, dizziness and mental side effects);Postoperative pulmonary complications (Respiratory tract infection, respiratory failure, pleural effusion, atelectasis, pneumothorax or bronchospasm); | — |
Countries
China
Contacts
Public ContactZhou Shuzhi
Ya'an People's Hospital
Outcome results
None listed