Chinese Herbal Medicine for Reducing Colorectal Adenoma (CRA) Recurrence: An Observational, Registry-based, Cohort Study and Qualitative Study in A Real-world Hospital Setting

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Observational

Source

ChiCTR

Registry ID

ChiCTR2200065713

Enrollment

Unknown

Registered

2022-11-13

Start date

2022-11-14

Completion date

Unknown

Last updated

2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Colorectal adenoma (CRA)

Interventions

Chinese herbal medicine treatment group:N/A

Non-Chinese herbal medicine treatment group:N/A

Eligibility

Sex/Gender

All

Age

18 Years to 75 Years

Inclusion criteria

Inclusion criteria: 1. Aged 18-75 years, no gender limit. 2. Diagnosed as the CRA if the pathological results of their colorectal lesion are the tubular, villous, or the combination of them (tubulovillous). 3. Had at least one and no more than six histologically confirmed colorectal adenomas (including tubular, tubulovillous, and villous adenoma) at a recent colonoscopy. 4. Performed polypectomy within the 2 months before recruitment with no residual adenomas. 5. Voluntarily participate in the trial and sign the consent form.

Exclusion criteria

Exclusion criteria: 1. Combined or prior history of familial adenomatous polyposis or hereditary nonpolyposis colorectal cancer (Lynch syndrome). 2. Patients with colorectal malignancies (including early and invasive carcinoma), or with a history of colorectal malignancies. 3. Patients with inflammatory bowel disease such as ulcerative colitis and Crohn's disease. 4. History of partial or total gastrectomy or enterectomy. 5. Serious heart, lung, cerebrovascular disease or cancer. 6. Can't tolerate colonoscopy. 7. Frequent changes in the working environment or other circumstances may easily lead to lost visits. 8. Participated in other clinical trials within the last 3 months. 9. Patients who are pregnant or trying to become pregnant, breastfeeding patients.

Design outcomes

Primary

Measure	Time frame
CRA recurrence rate;	—

Secondary

Measure	Time frame
Characteristics of recurrent CRA;Incidence of colorectal polyp (except for the conventional CRA).;Incidence of advanced CRA;Incidence of colorectal cancer;Improvement of symptoms;Faecal occult blood test (FOBT) result;Lipid level;Fasting plasma glucose test;Uric acid test;Short form health survey 36;Liver function;Kidney function;Adverse event;Carcinoembryonic antigen;Carbohydrate antigen 19-9;	—

Countries

China

Contacts

Public ContactZhang Beiping

Guangdong Provincial Hospital of Chinese Medicine

doctorzbp@163.com+86 20 81887233

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 8, 2026