None listed
Conditions
Interventions
Experimental group:Oral nephrotic nutritional supplements
Sponsors
Shanghai General Hospital, Shanghai Jiaotong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged >= 18 and<80 years; 2. Maintenance peritoneal dialysis, stable dialysis for more than three months; 3. Meet the PEW standard before enrollment, according to the PEW standard formulated by the expert group of the International Society for Renal Nutrition and Metabolism (IS-RNM) in 2008 : (1) Serum biochemical indicators: serum albumin<38g/L; Serum prealbumin level<0.3g/L; Serum total cholesterol level<1g/L; (2) Body mass index: body mass index (BMI)<23kg/m^2; The weight loss in 3 months was more than 5%, or in 6 months was more than 10%, and the total body fat content was less than 10% (bioelectrical impedance analysis (BIA) was used to measure body fat); At least one of the two criteria is met. 4. The study object understood and signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. After gastrointestinal resection; 2. Patients with acquired immunodeficiency syndrome or with acquired immunodeficiency virus infection; 3. Previous malignant tumor history; 4. Serious cardiovascular and cerebrovascular diseases (such as stroke and myocardial infarction); 5. Serious autoimmune diseases; 6. Have participated in or are participating in other clinical studies within three months; 7. Pregnant or lactating patients; 8. Type 1 diabetes or type 2 diabetes with HbA1c>9%; 9. Severe edema; 10. Acute gastrointestinal diseases occurred within 2 weeks before enrollment; 11. Take any oral nutritional supplements (whether or not for peritoneal dialysis patients) within 4 weeks before inclusion; 12. Allergies to any component of oral nutritional supplements; 13. Within 2 weeks before enrollment, he took orally any nutrition or health care products for the purpose of improving intestinal flora, antibiotics for any reason and other drugs that may interfere with the composition of intestinal flora; 14. Chronic diarrhea; 15. The efficiency of peritoneal dialysis is poor, Kt/v < 1.2.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Uremic toxin; | — |
Secondary
| Measure | Time frame |
|---|---|
| Intestinal microenvironment; | — |
Countries
China
Contacts
Public ContactRong Shu
Shanghai General Hospital, Shanghai Jiaotong University School of Medicine
Outcome results
None listed