The undelying brain mechanism of rTMS treatment for post-stroke depression

Status

Active, not recruiting

Phases

Early Phase 1

Study type

Interventional

Source

ChiCTR

Registry ID

ChiCTR2200065650

Enrollment

Unknown

Registered

2022-11-10

Start date

2022-11-10

Completion date

Unknown

Last updated

2023-05-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Post stroke depression

Interventions

1:iTBS stimulating left dorsal lateral prefrontal cortex

2:cTBS stimulating contralesional primary motor cortex

3:Sham stimulation

Eligibility

Sex/Gender

All

Age

40 Years to 75 Years

Inclusion criteria

Inclusion criteria: First-time ischemic stroke patients, 40–75 years old. 1. Diagnosis of stroke by neurologists; 2. First-time ischemic stroke, admitted < 6 monthd after stroke onset; 3. Unilateral focal brain lesions; 4. Diagnosed in conformity with the DSM-V diagnostic criteria; 5. NIHSS <15; 6. No contraindications to MRI scan.

Exclusion criteria

Exclusion criteria: Patients were excluded: 1. Brain dysfunction caused by other non-vascular causes; 2. History of depression, dementia and other psychiatric diseases; 3. MMSE < 19; 4. No show in the follow-up visit; 5. TIA or subarachnoid hemorrhage; 6. History of other neurologic diseases.

Design outcomes

Primary

Measure	Time frame
Depression scales;Functional brain metrics;Structural brain metrics;Cognitive assessments;	—

Countries

China

Contacts

Public ContactYating Lyu

Hangzhou Normal University/The Affiliated Hospital ofHangzhou Normal University

lvyating198247@gmail.com+86 13396508848

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Feb 4, 2026