acute lung injury
Conditions
Interventions
Control Group:Propofol combined with dexmedetomidine was continuously pumped intravenously
Experimental group:Sevoflurane inhalation combined with dexmedetomidine intravenously
Experimental group:Sevoflurane inhalation anesthesia
Control Group:Propofol was continuously pumped intravenously
Sponsors
the First Affiliated Hospital of Nanjing Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Patients undergoing segmental or lobectomy; 2. ASA I-II, age 18-65 years old, BMI: 18.5-28kg/m^2; 3. Patients without preoperative respiratory dysfunction and cardiovascular and cerebrovascular underlying diseases; 4. Sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. Patients who received radiotherapy, chemotherapy and immunotherapy within one month before surgery; 2. Patients with severe hypertension and those using angiotensin-converting enzyme inhibitor antihypertensive drugs with severe cardiovascular disease before surgery New York Heart Association (NYHA) class II and above; 3. Patients with abnormal liver and kidney function before surgery; 4. Those with fever or infection before surgery; 5. Patients with preoperative respiratory disease (COPD asthma pneumonia pulmonary edema history of pulmonary surgery); 6. Long-term smoking and drinking, those with cardiovascular and cerebrovascular diseases, metabolic diseases, and autoimmune diseases; 7. Have a history of narcotic and analgesic drug abuse and a history of mental and neurological diseases; 8. Those who have difficulty maintaining SPO2 above 95% during anesthesia; 9. Intraoperative estimated blood loss of more than 500ml or intraoperative blood transfusion and intraoperative hemodynamics difficult to maintain stable.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Partial arterial oxygen pressure;interleukin-6;Tumor necrosis factor-a;Tight junction protein;Glutathione;malondialdehyde;Glutathione peroxidase 4;Superoxide dismutase;The changes of lung histopathological ; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pulmonary complications; | — |
Countries
China
Contacts
Public ContactLinjia Zhu
The First Affiliated Hospital with Nanjing Medical University
Outcome results
None listed