type 3 pulmonary hypertension
Conditions
Interventions
Experimental group:recombinant human brain natriuretic peptide
Control group:placebo
Sponsors
Shengjing Hospital of China Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Hospitalized patients with acute exacerbation of chronic lung diseases, including: chronic obstructive pulmonary disease, bronchiectasis, obsolete pulmonary tuberculosis, obstructive sleep apnea hypopnea syndrome and thoracic or spinal deformity; 2. At rest, the systolic pressure of pulmonary artery measured by right heart Doppler ultrasound was >= 50mmHg; 3. At rest, the mean pulmonary artery pressure (mPAP) measured by Swan Ganz catheter was >= 25mmHg with PVR >= 3WU and PAWP = 18 years old, weight >= 30kg ~ = II.
Exclusion criteria
Exclusion criteria: 1. Any other types of pulmonary hypertension; 2. Other active respiratory diseases (such as active pulmonary tuberculosis, pulmonary fibrosis, etc.); 3. Patients requiring invasive mechanical ventilation; 4. At rest, PAWP measured by Swan Ganz catheter was >= 15mmhg; 5. Uncontrolled hypertension; 6. Systolic blood pressure = 5 µ 8. At rest, Doppler echocardiography confirmed left ventricular outflow tract obstruction or left ventricular systolic dysfunction (EF <= 55%); 9. Acute coronary syndrome; 10. Severe renal insufficiency (GFR < 30ml / min / 1.73m2); 11. Significant anemia; 12. Milrinone or levosimendan was used within 30 days before screening; 13. Allergic to any component of rhBNP; 14. Participated in other clinical trials within 30 days before screening; 15. Unable to complete the visit task.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Mean pulmonary artery pressure (mPAP); | — |
Secondary
| Measure | Time frame |
|---|---|
| Other hemodynamic parameters of pulmonary artery;PASP;6MWD( 6-minute walk distance);WHO fc;Oxygen partial pressure;dyspnea;NT-proBNP;acute event; | — |
Countries
China
Contacts
Public ContactLi Zhao
Shengjing Hospital of China Medical University
Outcome results
None listed